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Ritonavir may also increase blood concentrations of certain concomitant medications. Clinicians should be aware that many commonly used medications can be safely coadministered with ritonavir-boosted nirmatrelvir despite its drug-drug interaction potential. Because ritonavir-boosted nirmatrelvir is the only highly effective oral antiviral for the treatment of COVID, drug interactions that can be safely managed should not preclude the use of this medication. This list is primarily based on the most common medication searches by U. The progestin concentration of a combined hormonal contraceptive is expected to remain similar or increase with coadministration, which would maintain the effectiveness of the PO contraceptive. Clinicians should be aware that, in some cases, drug-drug interactions with ritonavir-boosted nirmatrelvir may lead to serious or life-threatening drug toxicities.
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