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It is the active ingredient found in the erectile dysfunction medication Cialis. Tadalafil can be purchased without the Cialis branding and is often referred to as 'generic Cialis'. It is just as effective, but because it is a generic medication, it usually costs less. Tadalafil is a long-lasting medication, working in as little as 30 minutes and lasting up to 36 hours. It's the longest lasting erectile dysfunction treatment currently available.