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The dubious online market in phosphodiesterase type 5 inhibitors is growing on a global scale. Within this work, genuine Cialis containing the active pharmaceutical ingredient API tadalafil, its generics available in the Czech Republic and the Cialis tablets from questionable online pharmacies were analysed. The methods of infra-red and Raman spectroscopy were used for the identification of the counterfeit tablets and for the verification of their API and excipients. All 9 tablets from online pharmacies were counterfeit with 2 of them even containing a different API sildenafil, vardenafil. In addition, Raman mapping was used to determine the API and excipients' distribution and, in combination with multivariate data analysis, to separate similar tablets in clusters and to identify the outliers. This comprehensive approach of analysis can be used for advanced exploration of the dubious samples of various medical products. Keywords: Cialis; Counterfeit medical products; Raman spectroscopy; Tadalafil; Vibrational spectroscopy. Abstract The dubious online market in phosphodiesterase type 5 inhibitors is growing on a global scale.
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