Other drugs for induction of ovulation, including letrozole, are discussed elsewhere. En-clomiphene is cleared rapidly, while zu-clomiphene has a long half-life 1. The two clomiphene isomers have mixed estrogenic and antiestrogenic effects that vary among species. En-clomiphene is the more potent isomer with greater antiestrogenic activity and the one primarily responsible for inducing follicular development 2. Clomiphene is cleared through the liver and excreted in feces. Over 50 percent of an oral dose of 14C-labeled clomiphene citrate is excreted after five days, but traces of radioactivity from the labeled clomiphene appear in the feces up to six weeks after administration.
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It works by stimulating the release of eggs from the ovary. Each tablet contains 50mg of the active substance, Clomifene Citrate The other ingredients are sucrose, lactose, soluble starch, maize starch, magnesium stearate, iron oxide yellow E, purified water.
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