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Clonazepam, sold under the brand names Klonopin and Rivotril, is a medication used to prevent and treat anxiety disorders, seizures, bipolar mania, agitation associated with psychosis, OCD and akathisia. Common side effects may include sleepiness, poor coordination, and agitation. Clonazepam was patented in and went on sale in in the United States from Roche. Clonazepam is prescribed for short-term management of epilepsy, anxiety, OCD and panic disorder with or without agoraphobia. Clonazepam, like other benzodiazepines, while being a first-line treatment for acute seizures, is not suitable for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects. Clonazepam has been found effective in treating epilepsy in children, and the inhibition of seizure activity seemed to be achieved at low plasma levels of clonazepam. Clonazepam has been found to be effective in the acute control of nonconvulsive status epilepticus ; the benefits, though, tended to be transient in many people, and the addition of phenytoin for lasting control was required in these patients. It is also approved for treatment of typical and atypical absences seizures, infantile myoclonic, myoclonic, and akinetic seizures. The effectiveness of clonazepam in the short-term treatment of panic disorder has been demonstrated in controlled clinical trials. Some long-term trials have suggested a benefit of clonazepam for up to three years without the development of tolerance, but these trials were not placebo -controlled.
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