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Strength This refers to the amount of the active medicinal ingredient e. Benefit Status Open - Drugs which are reimbursed with no criteria or prior approval. Note: a drug may have limitations that restrict usage. Limitations Drugs which are restricted to those individuals who meet the defined restriction requirements. Limitation based on age such as children under 12 years of age.

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Treatment of type 2 diabetes mellitus, particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycaemic control. After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. A slow increase of dose may improve gastrointestinal tolerability. Regular assessment of renal function is necessary see section 4. In patients at an increased risk of further progression of renal impairment and in the elderly, renal function should be assessed more frequently, e.

Clin Diabetes 1 January ; 40 1: 97— Originally synthesized nearly years ago in 1, it has been used in humans for more than 60 years 2. A decrease in hepatic neoglycogenesis has been the most frequently highlighted action 3, 4.

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