The mean half-life of unconjugated lorazepam in human plasma is» 12 hr and for its major metabolite, lorazepam glucoronide,» 18 hr. Treatment of status epilepticus; relief of chemotherapy-induced nausea and vomiting; acute alcohol withdrawal; psychogenic catatonia. Contraindications Psychoses; acute narrow-angle glaucoma; intra-arterial administration injection ; hypersensitivity to benzodiazepines. IV Initial dose: 2 mg total or 0. CNS: Drowsiness; confusion; ataxia; dizziness; lethargy; fatigue; apathy; memory impairment; disorientation; anterograde amnesia, restlessness; headache; slurred speech; aphonia; stupor; coma; euphoria; irritability; vivid dreams; psychomotor retardation; paradoxical reactions eg, anger, hostility, mania, insomnia. EENT: Visual or auditory disturbances; depressed hearing.
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Lorazepam 1mg Tablets are blue, capsule-shaped tablets, measuring approximately 4 x 8mm, plain on one face and 'gp' breakbar '19' on the other. Chronic use not recommended little is known of the long term safety and efficacy; potential for dependence—see section 4. Lower doses may be sufficient in these patients See section 4. Use in patients with severe hepatic insufficiency is contraindicated. Benzodiazepines should not be used alone in depression or anxiety with depression may precipitate suicide. Patients should be advised that since their tolerance for alcohol and other CNS depressants will be diminished in the presence of Lorazepam, these substances should either be avoided or taken in reduced dosage.
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