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Digoxin is a relatively safe, cheap and effective therapy for relieving recurrent symptoms in patients with congestive heart failure. It should be used as an adjunct to treatments known to reduce mortality e. The risk of digoxin toxicity can be minimised by using dosage regimens based on body weight and creatinine clearance, monitoring potential electrolyte imbalances and being aware of possible drug interactions. Particular caution is needed in the elderly who often require lower maintenance doses. Index words: atrial fibrillation, heart failure, adverse effects, dose regimens. The pharmacological management of congestive heart failure has improved significantly over the last decade. More recently, angiotensin AT 1 receptor blockers, beta blockers and carvedilol have also improved treatment strategies.
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Digoxin is used to treat heart failure and abnormal heart rhythms arrhythmias. This medication may be prescribed for other uses. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program.
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Digoxin is a compound in the drug family known as cardiac glycosides or cardenolides. Of the more than known digitalis compounds, two natural products have been used most often in clinical settings: ouabain and digoxin. Ouabain is derived from the plant Strophanthus gratus, and digoxin originates from the leaves of the purple foxglove Digitalis purpurea. Withering believed that digitalis produced a diuretic effect in those with an irregular, weak pulse and concomitant edema. The slowing of rate and rhythm are attributed to digoxin's impact on the central nervous system, leading to increased vagal activity that results in slowed conduction in the atrioventricular AV node. In fact, for more than years, digoxin was the main agent used for this indication.
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