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Type A adverse reactions are dose-related and can be predicted to occur through accidental overdose, individual differences due to age, disease or genetics or drugdrug interactions. Type B adverse reactions are rarer but potentially more serious. Many type B adverse reactions are due to allergy.

The human genome project and mapping of genes has led to work on the development of drugs to alter genes. The importance of pharmacology to health care professionals cannot be overestimated. Members of the three professions, physiotherapy, podiatry and radiography, encounter patients on a daily basis, many of whom will be on drug therapy. Patients are increasingly likely to be receiving at least one drug; many older patients are likely to be on more than one drug, and prescription of eight or nine drugs at the same time is not uncommon.

Psychostimulant drugs are used to treat ADHD, where paradoxically they have a calming effect and improve concentration and attentiveness in about should be under the guidance of a specialist in ADHD. Examples of drugs used to treat ADHD are dexamfetamine, methylphenidate and atomoxetine. These drugs inhibit the re-uptake of noradrenaline and dopamine. Increase in levels of these two transmitters in the prefrontal cortex is thought to increase inhibitory control in the limbic system.

Within the nervous system neurons make connections with each other called synapses. At the synapse, the neurons do not touch each other but are separated by a microscopic gap, the synaptic cleft. When a nerve impulse arrives at a synapse, chemical substances are released.

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Examples are given for each major group. The sulphonamides were the first drugs found to be effective in the treatment of systemic infections and although they do still have some specific uses, for example treatment of toxoplasma infections in patients with HIV, they are not much used nowadays because of bacterial resistance and the development of more effective drugs, which are less micronase cost uk. Silver sulfadiazine is used topically to treat infected wounds ( Sulphonamides inhibit an enzyme, dihydropteroate synthatase, used in the production of folic acid in many bacterial cells. Folic acid is the starting point for a cofactor necessary for DNA synthesis in both bacterial and human cells. However, in susceptible bacterial cells, folic acid must be synthesized, whereas in humans it is provided preformed in the diet.

Authored by Ashley Howell, FNP-C

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