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Perhaps lesser known is the effort by Spellberg and other clinicians to raise awareness of another longtime treatment dogma in infectious diseases that they believe deserves scrutiny: that IV-only therapy is the only way to treat certain conditions. He forecasted that it could be another decade at least before practice changes. Similarly, in, Francis A. No one ever tried to question it for decades. One such study, the POET trial, included patients with left-sided infective endocarditis who were randomly assigned to continue IV therapy or switch to step-down treatment with oral antibiotics after at least 10 days of initial IV treatment.
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