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Neuroleptic malignant syndrome NMS may be induced by atypical antipsychotic drugs AAPDs such as aripiprazole, olanzapine, risperidone and quetiapine, either as a single treatment or in combination with other drugs. A year-old female patient with a year history of bipolar disorder, being treated with lithium, fluoxetine, olanzapine, gabapentine, perazine and biperiden, was admitted to the hospital due to depressed mood and delusions. A urinary tract infection was diagnosed and antibiotic therapy was initiated. Her laboratory results revealed a toxic level of lithium 2. Acute renal failure was diagnosed and the lithium was withdrawn. After stabilization of her condition, and despite her antipsychotic treatment, further intensification of delusions and depressed mood were observed. All drugs being taken by the patient were withdrawn and lamotrigine and aripiprazole were initiated. There are many risk factors responsible for NMS development such as the use of high-dose, high-potency and long-acting antipsychotic drugs APDs, a rapid increase in the dosage of an APD, using multiple APDs or other medications like antidepressants and mood stabilizers, especially lithium. Previous NMS, dehydration, physical exhaustion, renal failure, a family history of catatonic syndrome and dementia can also put the patient at risk 2, 3, 4.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have any further questions, ask your doctor or pharmacist. This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.

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Lamictal DC Lamotrigine is used as an adjunctive therapy for partial seizures, primary generalized tonic-clonic seizures and seizures in patients affected by Lennox-Gastaut syndrome. In addition to this, physician may prescribe it for other types of seizures in patients with epilepsy. This medicine belongs to a class of drugs known as anticonvulsants antiepileptic drugs. When taken, it helps to reduce abnormal brain electrical cost crestor, which may help to treat seizures. Patients affected by bipolar disorder may sometimes be prescribed this drug to delay episodes of mania or depression.

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