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<p>Indicated for depressive episodes associated with bipolar I disorder in combination with fluoxetine. Safety of coadministered doses greater than olanzapine 18 mg with fluoxetine 75 mg have not been evaluated.</p>
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<p>Zyprexa IntraMuscular is indicated for the treatment of acute agitation associated with schizophrenia and bipolar I mania. Oral Zyprexa and fluoxetine in combination is indicated for the treatment of depressive episodes associated with bipolar I disorder. Oral Zyprexa and fluoxetine in combination is indicated for the treatment of treatment resistant depression major depressive disorder in patients who do not respond to 2 separate trials of different antidepressants of adequate dose and duration in the current episode. Zyprexa olanzapine is an atypical antipsychotic. The mechanism of action of olanzapine, in the listed indications is unclear. However, the efficacy of olanzapine in schizophrenia could be mediated through a combination of dopamine and serotonin type 2 5HT2 antagonism. Manic or Mixed Episodes, Bipolar I Disorder Adults - dry mouth, weight gain, increased appetite, dizziness, back pain, constipation, speech disorder, increased salivation, amnesia, paresthesia.</p><p>Olanzapine is an antipsychotic medication. These drugs affect chemicals in the brain. Fluoxetine and olanzapine is a combination medicine used to treat depression caused by bipolar disorder manic depression. This medicine is sometimes used after at least 2 other medications have been tried without success. Serious drug interactions can occur when certain medicines are used with fluoxetine and olanzapine.</p>
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<p>Manic or mixed episodes associated with bipolar I disorder in adults and adolescents ages Manic or mixed episodes associated with bipolar I disorder in adults as an adjunct to valproate or lithium. Depressive episodes associated with bipolar I disorder in children and adolescents ages Depressive episodes associated with bipolar I disorder in adults in combination with fluoxetine. Depressive episodes associated with bipolar I disorder in children and adolescents in combination with fluoxetine.</p>


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<p>Kaplan-Meier estimates of time to response. Median time to response for the olanzapine group 55 days was significantly earlier compared with the placebo group 59 days. Median time to response for the combined olanzapine-fluoxetine combination group 21 days was significantly earlier than for the olanzapine and placebo groups. Background Despite the longer duration of the depressive phase in bipolar disorder and the frequent clinical use of antidepressants combined with antipsychotics or mood stabilizers, relatively few controlled studies have examined treatment strategies for bipolar depression. Objective To examine the use of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression. Remission criteria were met by </p>
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<p>Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening and emergence of suicidal thoughts and behaviors. Advise families and caregivers of the need for close observation and communication with the health care provider. Individual ingredient products offer lower dose strengths; consider combination or individual ingredient products based on individual patient dose requirements. Adjust dose based on response and tolerability. Discontinuation of therapy: See individual agents.</p>
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<p>Patients with bipolar disorder spend half their lives significantly symptomatic, mainly in the depressive phase. Antidepressant drugs are commonly used, but recent data question the effectiveness of this practice. An olanzapine-fluoxetine combination OFC, FDA-approved for treating bipolar type I depression, has demonstrated efficacy in clinical trials. Most atypical antipsychotics—including olanzapine—are potent 5-HT 2A serotonin receptor antagonists. This effect is similar to that of some antidepressants and may mediate some antidepressant and antianxiety effects of these drugs. Like most atypicals, olanzapine is also a potent 5-HT 2C blocker.</p>

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