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Action Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis. Indications Indomethacin: Symptomatic treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis, acute painful shoulder. Suppositories contraindicated in recent bleeding or proctitis history. Anticoagulants: May increase risk of gastric erosion and bleeding. Beta-blockers, ACE inhibitors: Antihypertensive effects may be decreased.

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