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Not for oral, ophthalmic, or intravaginal use. Instruct patient to wash face with a non-medicated soap, then apply a thin film of the cream, lotion, or gel to cover the entire face; avoid eyes, lips, and mucous membranes. According to the manufacturer, adapalene should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. There are no adequate and well controlled studies in pregnant women. Further, during clinical trials women of childbearing potential initiated treatment only after negative pregnancy tests were obtained. These teratogenic changes included cleft palate, microphthalmia, exophthalmos, encephalocele, skeletal abnormalities, umbilical hernia, and kidney abnormalities.
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