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When — and how — should you be screened for colon cancer? The release of the first beta blocker in the early s revolutionized the treatment of chest pain caused by exertion or stress angina. Today, millions of Americans take a beta blocker. This medication spotlight looks at how beta blockers work, who can benefit from them, and what to expect if you take one. There are three main types. Beta-1 receptors are found almost exclusively in heart cells.

Beta-2 receptors reside mostly in lung and blood vessel cells, though heart cells also have some. Beta-3 receptors are located on fat cells. The job of beta receptors is to latch onto chemical messengers released by the nervous system. In response to these messengers, the heart beats faster, blood vessels constrict, the airways relax, and the kidneys increase production of a protein that boosts blood pressure.

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You can tell a beta blocker by its generic name — they all end in lol. More than a dozen beta blockers have been approved for use in the United States see table. They fall into three main groups. The earliest beta blockers, like propranolol, affect both beta-1 and beta-2 receptors. Nonselective beta blockers should be used with caution, if at all, in smokers or people with asthma or other lung conditions.

A number of beta blockers, including atenolol Tenormin and metoprolol Toprol, Lopressor, were designed to block only beta-1 receptors in heart cells. Some beta blockers do more than block beta receptors.

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