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<p>Background: Calcineurin inhibitors CNIs represent the cornerstone of immunosuppressive therapy after liver transplantation. Based on the NMA findings, the present study evaluated the cost-utility of PR tacrolimus relative to ciclosporin or IR tacrolimus in liver transplant recipients in the UK. Methods: A Markov model was developed to evaluate the cost-utility of immunosuppressive regimens in liver transplant recipients, capturing costs associated with immunosuppression, retransplantation, acute rejection AR, and cytomegalovirus infection. Relative to ciclosporin, QALE increased by 1. The prograf price uk limitations of the study were data source heterogeneity and omitting the economic and clinical effects of treating aspects of recurrent liver disease. GM and IO are full-time employees of Astellas Pharma Euope Limited, which manufactures immediate-release and prolonged-release tacrolimus.</p>
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