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Objective: To present an economic model and cost-effectiveness estimates for lamotrigine in maintenance treatment of bipolar I disorder BD-I using outcomes from the pivotal lamotrigine trials. The main comparator treatments in the pivotal trials were lithium and. Methods: A Markov model was built around the 3 health states of euthymia, mania, and depression. The base-case model simulates a cohort of 1, patients with BD-I who have recently stabilized after resolution of a bipolar mania episode. The cohort was modeled for a buy phenergan tablets of 18 months.

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To estimate the cost-effectiveness of rufinamide relative to topiramate and lamotrigine as adjunctive treatment for children with Lennox—Gastaut Syndrome LGS. A Markov decision analytic model was developed to estimate the incremental cost-effectiveness ratio over a three-year time horizon in patients with LGS uncontrolled by up to three antiepileptic drugs. Outcomes included costs and quality-adjusted life-years QALYs, allowing the incremental cost-effectiveness ratio to be estimated as cost per QALY gained. Rufinamide resulted in an incremental QALY gain of 0. Considering the underlying assumptions, this current economic evaluation demonstrates that rufinamide is likely to be a cost-effective alternative to topiramate as adjunctive treatment for children with LGS in the UK. Author links open overlay panel Lara Verdian a Yunni Yi b.

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