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Split tablets of lisinopril are as effective as whole tablets of the same dose for hypertension SOR: B, based on small randomized crossover study. Similarly, split tablets of atorvastatin, lovastatin, and simvastatin are no less effective for lowering cholesterol SOR: B, based on retrospective cohort studies. However, the cost savings garnered by splitting these types of tablets is often limited. However, splitting drugs with a long half-life and wide therapeutic index—such as those used to treat chronic asymptomatic conditions like hypertension or dyslipidemia—should pose minimal risk. Few studies have looked at the clinical effects of pill-splitting. There was no difference in blood pressures between groups.
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