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The IVM concentration profiles measured in plasma and respiratory tract tissues nasopharynx and lungs after the nasal spray treatment one and two applications were compared with those achieved after the oral administration. Significant increases in IVM concentration profiles in both NP-tissue and lungs were observed after the 2-dose nasal administrations. The fast attainment of high and persistent IVM concentrations in NP tissue is the main advantage of the nasal over the oral route. Subject Area Pharmacology and Toxicology. Animal Behavior and Cognition Pharmacology and Toxicology
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Melasma is a pigmentation disorder of the skin mostly affecting women, especially those with darker skin. It is commonly seen on the face, and appears as dark spots and patches with irregular borders. Melasma is known as the mask of pregnancy since hormonal changes caused by pregnancy, as well as hormonal medications such as birth control pills, are major triggers for excessive skin pigment production in melasma. Sun exposure is another important contributor to melasma. Currently, melasma cannot be fully prevented in people who are likely to develop this condition due to their genetics, skin color type, hormones, or sun exposure level.
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