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Tramadol represents the category of synthetic analgesics and is referred to the group of opioids. The medication provides a noteworthy effect on the CNS and spinal cord, causing membrane hyperpolarization and braking pain impulses. It produces a powerful analgesic effect that lasts for a relatively long time roughly 6 hours. Tramadol, based on the active substance of the same name, is a selective agonist of the mu-opioid receptor; its action aims at inhibiting the reverse neuronal uptake of serotonin and norepinephrine. Considering the dosage options specified in the insert, the drug does not produce significant effects on respiration and hemodynamics, neither it changes the parameters of pulmonary artery pressure, and finally, it has no significant inhibitory effect on intestinal motility. The onset of analgesic effect is observed within up to 30 minutes after the reception, it is maintained for approximately 6 hours.
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Tramadol, sold under the brand name Ultram among others, 1 is an opioid pain medication and a serotonin—norepinephrine reuptake inhibitor SNR used to treat moderately severe pain. As is typical of opioids, common side effects include constipation, itchiness, and nausea. Tramadol is used primarily to treat mild to severe pain, both acute and chronic. For severe pain it is less effective than morphine. Pain reducing effects last approximately six hours.
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