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This is the recommended dose if you found 50mg effective, but you experienced side effects at this strength. Erectile dysfunction ED is caused by a range of physiological and psychological conditions like stress, anxiety, or depression. The mechanical problem is commonly the same: insufficient blood flow or nervous stimulation, which is required to enable enough blood into the penis to achieve a full and sustained erection. ED can be the first sign of heart or other health conditions, including cardiovascular disease and diabetes. However, ED can also affect younger men - in a recent study it was found that one in four patients seeking first medical help for new onset ED was younger than 40 years.
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Generic medicines are required meet the same standards of safety, quality and efficacy as the branded medication. To receive market approval from the European Medicines Agency and MHRA, a generic medicine must be 'bioequivalent' to the originator product.
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Common side effects include headaches, heartburn, and flushed skin. Sildenafil acts by blocking phosphodiesterase 5 PDE 5, an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. The primary indication of sildenafil is treatment of erectile dysfunction inability to sustain a satisfactory erection to complete intercourse. Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction. Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon ; these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes.