Although nation-wide epidemiological data are currently sparse, provincial data and data from the US indicate an area of growing concern. Concurrent with this increase in the general availability are additional opportunities for non-medical use. Additionally, US studies have indicated lower socio-economic status, with associated variables such as poverty, unemployment or low income as risk factors for NMUPO in the general population. Specific analyses of socio-demographic characteristics of PO clients in treatment facilities are currently not available. BDs are consumed at lower prevalence levels that POs and consumption rates have remained relatively stable over time. Additionally, there is some evidence suggesting healthcare worker involvement in diverting BDs. Despite a lack of research exploring possible associations between NMUBDs and overdose deaths in Canada, international studies have identified drug poisoning by BDs in approximately 3.
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To determine the therapeutic effects of two selective GABA-A agonists, zopiclone and eszopiclone, in the treatment of insomnia. Patients were randomized to receive zopiclone 7. The primary endpoint was the Insomnia Severity Index after four weeks of treatment. Secondary endpoints were obtained through polysomnography data, including total sleep time, sleep latency and sleep efficiency. The frequency of adverse events was also analyzed.
Public angst over the abuse of painkillers is overshadowing what Canadian researchers say is an even more pressing problem: the nation's growing love affair with sleeping pills. Yet the use of benzodiazepines and other drugs prescribed for sleep is even more deeply ingrained in our culture than the use of opioids, said Deborah Cumming, national priority adviser at the Canadian Centre on Substance Abuse. The pills have become so ubiquitous, so normalized, that some say they are like the new Aspirin. Women are also drinking more, making for a potentially lethal multi-drug mix. Canadians are not only being increasingly prescribed traditional sleep drugs, but powerful antipsychotics once reserved for schizophrenia and mania are now also being used for the treatment of insomnia. The drugs are heavy-hitting tranquillizers that should never be used for insomnia unless the patient has an underlying major psychiatric disorder, sleep specialists say.
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Zaleplon, sold under the brand name Sonata among others, is a sedative and hypnotic which is used to treat insomnia. It is a nonbenzodiazepine or Z-drug of the pyrazolopyrimidine class.
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